Dr Raj talks about the Hormonal Causes for Tiredness & Weight Gain

Dr C Rajeswaran (Raj), Consultant Bariatric Physician & Endocrinologist
Claremont Clinics: Thursday PM



We all have felt tired sometimes, which may be due to change in routine, lack of sleep or stress. However constant tiredness or a feeling of lack of energy, which is persistent and unexplained requires consultation with a doctor and needs further investigations.

Most people feel tired when they have flu like illness, anaemia, medical conditions like heart disease, kidney disease, poorly controlled diabetes mellitus etc. Tiredness is also experienced when anxious and depressed. Here is list of some of the hormonal causes for tiredness:

  • Addison’s disease (Low cortisol)
  • Hypothyroidism (Low thyroid hormones)
  • Diabetes mellitus (High blood glucose)
  • Pituitary and hypothalamic (Low cortisol, growth hormone, Thyroid & sex hormones, altered salts)
  • Hypogonadism in men (Low testosterone)
  • Pre-menstrual syndrome (low progesterone and/or high oestrogen)
  • Menopause
  • PCOS (Elevated testosterone and insulin)
  • Leptin deficiency
  • 1Insulin deficiency or excess or insulin resistance related conditions
  • Cushing’s syndrome/disease (High cortisol)
  • Acromegaly (Elevated growth hormone)


Weight Gain

There are several causes for weight gain. Hormonal disturbance in the body plays a key role in regulation of body weight. Altered hormone levels may either disturb hunger, fullness or metabolism leading to weight gain. Occasionally there may be a combination of several of these factors contributing to weight gain. Here is a list of some of the conditions which may cause weight gain:

  • Acromegaly
  • Anxiety or extreme psychological stress
  • Brain injury
  • Cushing’s disease/syndrome
  • Gestational diabetes
  • Growth hormone deficiency
  • Hyperphagia due to excess ghrelin
  • Hypogonadism/Andropause
  • Hypogonadotropic hypogonadism
  • Hypothalamic obesity
  • Hypothyroidism
  • Insulinoma
  • Leptin deficiency
  • Menopause
  • Polycystic ovary Syndrome (PCOS)
  • Post pregnancy
  • Premenstrual syndrome (PMS)
  • Reactive hypoglycaemia


What to do next…

It is important to remember that you do not need investigation of these causes unless there is a strong suspicion by an endocrinologist. An initial private consultation with Dr C Rajeswaran (Raj) costs £200.  For more information or to book an appointment, call our Private Patient Team on 0114 263 2114 or email You will need a referral letter from your GP or you can see one of our Private GPs quickly for this if you prefer.

Copyright Dr Rajeswaran 2019

Date: 07/05/2019
By: Paula
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